Isoindole Linkages Provide a Pathway for DOPAL-Mediated Cross-Linking of α-Synuclein
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چکیده
منابع مشابه
Dopamine-Mediated Oxidation of Methionine 127 in α-Synuclein Causes Cytotoxicity and Oligomerization of α-Synuclein
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective loss of dopaminergic neurons and the presence of Lewy bodies. Many recent studies focused on the interaction between α-synuclein (α-syn) and dopamine in the pathogenesis of PD, and fluorescent anisotropy suggested that the C-terminal region of α-syn may be a target for modification by dopamine. However, it i...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2018
ISSN: 0006-2960,1520-4995
DOI: 10.1021/acs.biochem.7b01164